Mai 2010

• Additionally proteomics data:
  Vögtle et al.,2009

• The dataSets for Mouse, Human and Arabidopsis thaliana have been fully updated from the Integr8 database .
• The list of mitochondrial human and mouse proteins has been improved through the manual annotation work from the "Institut for human genetics" team.
• Orthologous analysis is most based on the CluSTr database which offers an automatic classification of UniProt Knowledgebase and IPI proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences.

Mouse:

• update of the chromosomal localization datas
  UCSC genome July 2007 assembly data
• November 2008 update of the Mutant phenotypes data compiled in the MGD database
• Additionally proteomics data:
  Lee et al., 2008
• New prediction data of mitochondrial localization :
  prediction score (maestro) defined as a log-likelihood of mitochondrial localization (Naive Bayes integration) through integration of 8 genome wide methods. See: A Mitochondrial Protein Compendium elucidates Complex I Diseses Biology, Pagliarini et al., 2008

Human:

• New prediction data :
  possibility is given to the user to filter for human proteins with mouse homologs predicted as mitochondrial according to the maestro score (see above)

Human:

• Basis data set: Integr8 release, 31-05-2006
• Mitochondrion sublocalization predictions: complete new calculations with psort, predotar, subloc programs
• Actualization of annotation of the mitochondrial reference set by Holger Prokisch.
• USCS chromosomal mapping: hg18 release - Mar 2006 assembly
• Additionally proteomics data:
Lescuyer et al., 2003
Xie et al., 2005
Fountolakis et al., 2005
Devreese et al., 2006
McDonald et al., 2006 (human homologs from proteome rat data were saved here)

• New calculation of the mitochondrial localization prediction with a support-vector machine

Mouse:

• Basis data set: Integr8 release, 31-05-2006
• USCS chromosomal mapping: mm8 release - Feb 2006 assembly
• Additionally proteomics data: Calvo et al., 2006
• New and improved calculation of the mitochondrial localization prediction with a support-vector machine

A. Thaliana

• Basis data set: downloaded from TAIR database, Juli 2007 link
• subcellular localization with green fluorescent protein : downloaded from SUBA database
• Additionally proteomics data:
  Heazlewood et al., 2004
  Dunkley et al., 2006
• incorporation of the Arabidopsis Mitochondrial Protein Database datasets link